Specifically, 25 out of 245 downregulated genes upon TLR2 knockdown were shared with AF-upregulated DEGs (p < 0.001), and 13 out of 247 downregulated genes upon TLR3 knockdown were shared with AF-upregulated DEGs (p = 0.0241). The gene discussed is TLR3; the disease is atrial fibrillation.