Over 150 disease-associated variants leading to a variety of retinal degenerations, most commonly to Leber congenital amaurosis and early-onset rod–cone dystrophy (52%) but also to retinitis pigmentosa (25%), have been described in the CRB1 gene by the Human Gene Mutation Database (http://www.hgmd.org, last accessed on 7 January 2024) [9]. Here, CRB1 is linked to retinal degeneration.