CRB1 and respiratory distress syndrome in premature infants: On the other hand, proof-of-principle studies for treating CRB1-associated IRDs showed efficient CRB1 expression but adverse effects on retinal activity in CRB1 murine models, which could be caused by the replacement of the CRB1-A isoform but not the other CRB1-B isoform [44,45,46].