For instance, POLR1C (polymerase (RNA) I polypeptide C, 30 kDa) had the largest up-regulation in both cell culture lines even as its expression level was not significantly changed in the malignant part of the surgically removed tumor (x(T) = −1.09; x(Φ) = 198.71; x(Θ) = 221.73). The gene discussed is POLR1C; the disease is neoplasm.