POLR2L and cancer: By the most comprehensive measure (Transcriptomic Distance, TD (Figure 5c)), POLR2L had the largest contribution to the overall cancer-induced transcriptomic alteration within this gene subset in T (TD(T) = 145, TD(Φ) = 497, TD(Θ) = 495) and GTF2I in both cell lines (TD(T) = 45, TD(Φ) = 964 TD(Θ) = 872).