Furthermore, our pathway enrichment analysis (Supplementary Table S5) showed that the pathways related to leukemia and Alzheimer disease were significantly enriched by genes differentially expressed in the fetal brain of the short-lived mice (Supplementary Table S5), suggesting that these pathways were regulated in the developing brain of the AKR/J and Cav1-null mice which show leukemia and Alzheimer disease, respectively, later in life. Here, CAV1 is linked to early-onset autosomal dominant Alzheimer disease.