Consistently, significant decreases in Dpt expression were also observed in miR-310-, miR-311-, and miR-312-overexpressing flies after the challenge (Figure 3C–E, respectively), whereas the knockdown of miR-310/miR-311/miR-312 led to significantly increases in Dpt expression in miRNA sponge lines (tub-G80ts; tub > miR-310 SP, tub-G80ts; tub > miR-311 SP, and tub-G80ts; tub > miR-312 SP), compared with control flies at 6 h and 12 h post infection (Figure 3C–E). The gene discussed is DPT; the disease is infection.