Overall, a positive AURKC mutation is found in 50.8–100% of macrozoospermic patients and nearly all positive mutated AURKC patients have a typical phenotype, with high percentages of large-head spermatozoa, indicating AURKC mutation as the only well-known and well-studied causative genetic mutation of macrozoospermia [5,132]. Here, AURKC is linked to spermatogenic failure 5.