Interestingly, the haplotype-association analyses indicated that the AGG haplotype (contributed by the rs2853550, rs1143634, and rs1143627 variants in IL-1β) was approximately four times more frequent in infected than in non-infected individuals (12.86% vs. 3.22%, p = 0.017) and strongly associated with PJI (Table 7). Here, IL1B is linked to juvenile polyposis syndrome.