It could be argued that, in our cohort of THA and TKA patients, the rs3024491-A variant in IL-10 was associated with a lower probability of PJI (OR = 0.47; 95%CI = 0.26–0.86), while the rs2853550-A variant in IL-1β was associated with a higher probability of infection (OR = 4.05; 95%CI = 1.28–12.93). This evidence concerns the gene IL10 and infection.