Keeping in mind that ATAs are generally linked to the diffuse form of the disease and that ACAs are linked to the limited form, HLA-DRB1*01, HLA-DRB1*04, HLA-DRB1*08, HLA-DQB1*0501, HLA-DDQB1*26 haplotypes linked to the presence of ACA antibodies may suggest an association with limited systemic sclerosis [35,37,38]. This evidence concerns the gene HLA-DRB1 and limited cutaneous systemic sclerosis.