These likely pathogenic missense variants were in SCNN1B [c.1688G > A p.Arg563Gln; MAFNAVARREsel = 0.013, MAFNAVARREval = 0.016] and in PTGIS [c.824G > A p.Arg275Gln; MAFNAVARREsel = 0.013, MAFNAVARREval = 0.021], associated with “low renin hypertension” and “childhood-onset schizophrenia”, respectively, according to ClinVar [18]. The gene discussed is PTGIS; the disease is Rare pervasive developmental disorder.