In a recent study published by Sebert et al. in which they analyzed 335 FA patients from the French registry, the main somatic lesions involved SVs rather than point mutations, the most frequent alterations being partial or total 1q gains (51.6%), partial 3q gains (40.3%), partial loss of 7q or monosomy 7 (30.6%), and lesions at 21q22 altering the RUNX1 locus (22.6%). Here, RUNX1 is linked to Friedreich ataxia.