FH and hereditary leiomyomatosis and renal cell cancer: Heterozygous germline fumarate hydratase (FH) mutations have been demonstrated to be associated with an autosomal dominant disease named multiple cutaneous and uterine leiomyomatosis (MCUL) [54], as well as a rare disorder known as hereditary leiomyomatosis and renal cell carcinoma (HLRCC) [55,56].