SATB1 is currently associated with developmental delay with dysmorphic facies and dental anomalies (DEFDA, MIM#619228) and with the Den Hoed-de Boer-Voisin syndrome (MIM#619229), two autosomal dominant disorders characterized by variable facial dysmorphisms, global developmental delay, poor or absent speech, altered electroencephalogram (EEG), and brain abnormalities on imaging. The gene discussed is SATB1; the disease is Global developmental delay.