Although several studies identify SATB1 as a promoter of tumor cell growth and an inhibitor of apoptosis [2], large exome sequencing studies, integrated with statistical analyses, showed the gene to be potentially involved in brain development; the identification of de novo variants in large cohorts of subjects with neurodevelopmental disorders confirmed its contribution to the pathogenesis of these conditions [3,4,5]. Here, SATB1 is linked to neurodevelopmental disorder.