Our search strategy, (Table 1) in the PubMed database involved the utilization of specific MeSH terms, including “Colorectal Neoplasms”, “Metastatic “, “Molecular Targeted Therapy”, “Precision Medicine”, and “Mutation”, along with related terms such as “BRAF “, “KRAS “, “NRAS “, “ERBB2 “, “Microsatellite Instability”, “DNA Mismatch Repair”, “Immunotherapy”, “Antineoplastic Agents “, “Biomarkers, Tumor”, “Circulating Tumor DNA”, “Drug Resistance, Neoplasm”, and “Clinical Trials”. The gene discussed is BRAF; the disease is neoplasm.