On the other hand, methylation data from the Infinium Human Methylation 450 BeadChip (HM450, Illumina) visualized in cBioPortal for the CD44 gene indicate that methylation levels present an inverse correlation with CD44 mRNA expression (Figure 2B, right panel), providing preliminary evidence for the regulation of CD44 expression by gene methylation in ccRCC. The gene discussed is CD44; the disease is nonpapillary renal cell carcinoma.