In an effort to identify the molecular background of CD44 gene upregulation in ccRCC, we employed CD44 copy number and methylation data from TCGA, then analyzed and visualized through the cBioPortal (Kidney Renal Clear Cell Carcinoma, https://cbioportal.org/study/summary?id=kirc_tcga_pub, accessed on 16 December 2023) [16,17]. This evidence concerns the gene CD44 and nonpapillary renal cell carcinoma.