In contrast, in a transcriptomic study comprising 210 PitNET with immunohistochemical validation in 77 of these lesions, Luo et al. found that POU1F1-derived neoplasms had a significant increase in M2 macrophages than TBX19- and NR5A1-derived PitNET or non-tumoral pituitaries [16]. Here, POU1F1 is linked to neoplasm.