This immune gene signature segregates along each tumor lineage and the transcription factor that determines their terminal differentiation: POU1F1-dependent GH-, TSH-, PRL-secreting PitNET; NR5A-1-driven gonadotrophinomas; and TBX19-dependent ACTH-secreting PitNET (Figure 1A). This evidence concerns the gene NR5A1 and neoplasm.