EGF and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1: Today, with the increasing number of experimental data from patients with CADASIL syndrome, it is possible to create a mathematical model through which we will be able to relate the order and the series of mutations in different EGF-like repeats based on a specific phenotype of the disease, as well as based on sex and age [38,50,60,61].