Other solid tumors that commonly harbor BRAF V600E mutations include papillary thyroid cancer, serous ovarian cancer, and colorectal cancer [3], to list a few, while BRAF V600E-mutant hematologic malignancies include hairy cell leukemia (HCL) [4,5] and histiocytic neoplasms, such as Langerhans cell histiocytosis (LCH) [3]. This evidence concerns the gene BRAF and Langerhans cell histiocytosis.