CNP and leukodystrophy: The other molecular mechanisms associated with leukodystrophies include defects in the mitochondrial proteins (cerebrotendinous xanthomatosis); cytoskeletal proteins (autosomal dominant leukodystrophy with autonomic disease); transcription (4H leukodystrophy) and translation (tRNA synthetase-related leukodystrophies); myelin structural proteins (CNP-related hypomyelinating leukodystrophy and Pelizaeus–Merzbacher Disease); cell junction; and other transmembrane proteins [9,10,11,12,13,14,15,16,17].