As Figure 3B shows, the expression level of TNF‐α, IL‐6, IL‐1β and high mobility group box 1 (HMGB1) were elevated in TG and HG group, indicating both transient and lasting hyperglycaemia exaggerated LPS‐induced inflammation in macrophages (Figure 3B; Appendix Figure 3D–G). Here, HMGB1 is linked to Hyperglycemia.