The distinct polarization of neutrophils contributes to their heterogeneous roles in tumor development.[11, 12, 13] In the binary N1/N2 model, N2 neutrophils are described as an immunosuppressive subtype[14] and promote tumor development by impairing the antitumor immunity of CD8+ T cells[15, 16] and NK cells.[17] Several metabolic shifts are reported to occur in tumor‐associated neutrophils (TANs). Here, CD8A is linked to neoplasm.