CA9 and neoplasm: Despite microsatellite instability, immunocyte distribution can also vary between tumor core and margin.[24] We used hypoxia marker carbonic anhydrase 9 (CAIX/CA9) to specifically label the core region of tumor tissues as previously reported,[25, 26] and immunofluorescence staining showed that the number of infiltrating CD16+ neutrophils were comparable between tumor margin and core (Figure S1E,F, Supporting Information).