NFKB1 and colorectal carcinoma: Furthermore, CD16 was found to possess signal transduction function and could influence the phenotype of macrophages and neutrophils through its downstream signaling pathway.[41, 57] In this study, we found that the activation of the CD16/TAK1/NF‐κB axis in CD16+ neutrophils is indispensable for the immunosuppressive role of neutrophils in CRC.