Notably, we identified a significant increase in the expression of EGFR and EpCAM, known downstream target genes of β‐catenin (Figure 3E).[21, 22] The cross‐talk between EGFR and β‐catenin or EpCAM and β‐catenin played a critical role in the progression and cancer stem cell features of HCC.[23, 24] Subsequent GSEA analysis using gene signatures derived from wild‐type and Nr2e3−/− liver tumor tissues indicated high enrichment of WNT/β‐catenin signaling pathway in the Nr2e3−/− mice (Figure 3F). The gene discussed is EPCAM; the disease is hepatocellular carcinoma.