These results are consistent with previous reports showing overexpression of Sp1, β‐catenin, and p300 and their correlation with poor clinical outcomes in HCC.[36, 37, 38] Next, we determine whether patients expressing high Sp1, β‐catenin, or p300 levels exhibited enhanced enrichment of the Wnt/β‐catenin signaling pathway. This evidence concerns the gene EP300 and hepatocellular carcinoma.