Specifically, concentrations of CC chemokines (CCL1, CCL4, CCL7, CCL8, CCL11, CCL13, CCL15, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26 and CCL27) and CXC chemokines (CXCL2, CXCL5, CXCL6, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12, CXCL13, CXCL16 and CX3CL1) were higher in the diabetic eye disease patients than in the controls. The gene discussed is CCL21; the disease is diabetic eye disease.