Second is exogenous resistance of these cells, such as T-cell deletions; expression of other inhibitory molecules, such as V-domain Ig suppressor of T cell activation (VISTA), lymphocyte-activation-protein 3 (LAG-3), and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3); and recruitment of tumor-associated macrophages and Tregs. The gene discussed is VSIR; the disease is neoplasm.