It was found that high myopic associated proteins (ASXL1 FGFR3 ERBB3 SOX4) can affect ARID1B protein by affecting ARIDIA protein, and COL2A1 protein can also affect ARIDIA protein by affecting FGFR3 protein, resulting in the clinical phenotype of patients with high myopia (Fig. 7). The gene discussed is COL2A1; the disease is myopia.