CTLA4 and type 1 diabetes mellitus: Immunointerventions, such as anti-CD3 monoclonal antibodies (teplizumab) [40], transplantation of autologous Tregs [41], anti-thymocyte globulin [42] and CTLA-4-immunoglobulin (abatacept) [43], have been tested in T1D patients in pre-clinical stage 2 and recently diagnosed, in stage 3, for this purpose.