Additionally, a previous study has indicated increased ARG1 expression in peripheral blood and bone marrow of bortezomib-refractory multiple myeloma patients,observed that in bortezomib-refractory multiple myeloma patients, ARG1 was increased in peripheral blood and bone marrow, suggesting that arginase-induced arginine deprivation may protect the myeloma cell from bortezomib-induced apoptosis (Giallongo et al. 2022). This evidence concerns the gene ARG1 and plasma cell myeloma.