In contrast, the enriched pathways of the downregulated genes included those related to DNA damage repair, such as “Nucleotide excision repair (NER) Enhanced Pathway,” “Hereditary Breast Cancer Signaling,” and “Role of BRCA1 in DNA Damage Response” (−log(p value) = 9.27, 8.51 and 7.38, respectively) (Fig. 3b). The gene discussed is BRCA1; the disease is breast cancer.