The most significantly downregulated genes in T1D enteroids included genes related to: intracellular transport: ATP6V0D2 (H + -ATPase, also known as vacuolar ATPase, V-ATPase), cell–cell communication: GLDN (Gliomedin: mediates interaction between Schwann cell microvilli and axons), CXCL5 (C-X-C motif chemokine 5, also known as epithelial-derived neutrophil-activating peptide 78), immunosuppression: IL19 (interleukin-19), and maintenance of intracellular pH: MCTs (Monocarboxylate transporters: SLC16A6, and A14). The gene discussed is ATP6V0D2; the disease is type 1 diabetes mellitus.