Among the most significantly upregulated genes in the T1D enteroids compared with HS were genes related to the control of cell cycle progression: DDX3Y (DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide, Y), translation initiation factor: EIF1AY (Eukaryotic Translation Initiation Factor 1A Y-Linked), histone modification: UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked), KDM5D (lysine demethylase 5D), GTPase activator: RGPD1 (RANBP2 Like And GRIP Domain Containing 1), and cAMP-dependent serine/threonine protein kinase activator: PRKY (protein kinase Y linked). Here, KDM5D is linked to type 1 diabetes mellitus.