Initial analysis of the internal test set by multiple linear regression (Fig. 3a,b) revealed that lower HECTOR risk scores were associated with established favorable risk factors of endometrioid (EEC) histological subtype, grade 1 and POLEmut EC, and higher HECTOR risk scores with unfavorable factors, including non-EEC histological subtypes, grade 3, FIGO stage III, LVSI, p53abn EC, estrogen receptor negativity and L1 cell adhesion molecule (L1CAM) positivity (Supplementary Tables 7–9 and Supplementary Fig. 13). Here, ESR1 is linked to exstrophy-epispadias complex.