While recent studies have reported certain coding and noncoding EIF2AK3 SNVs as genetic risk factors in several neurodegenerative diseases, including AD and PSP (Hoglinger et al. 2011; Stutzbach et al. 2013), this is the first study to demonstrate an association between multiple coding and noncoding EIF2AK3 SNVs and cognition in PWH. The gene discussed is EIF2AK3; the disease is Alzheimer disease.