In light of the evidence showing increased or sustained PERK activity as detrimental to several critical cellular pathways in a wide range of conditions and based on the possibility of a link between specific minor alleles of EIF2AK3 and neurodegenerative diseases with features shared by NCI in PWH, we hypothesized that minor EIF2AK3 alleles such as haplotype B-associated SNVs are a risk factor for NCI in PWH. Here, EIF2AK3 is linked to neurodegenerative disease.