NO–sGC–cGMP pathway dysfunction has been linked to hypertension, clinically significant portal hypertension, heart failure, and chronic kidney disease (Sandner et al. 2021; Wobst et al. 2015; Morales-Ruiz et al. 2015; Langer and Shah 2006); moreover, nitrates (as a source of NO) play important clinical roles in the treatment of coronary heart disease (Giuseppe et al. 2015; Collet et al. 2021). The gene discussed is SGCB; the disease is hypertensive disorder.