SIRT6 and diabetic cardiomyopathy: The endothelium-specific knockout of Sirt6 induced EndoMT and increased the expression of proinflammatory cytokines in murine carotid arteries (Chen et al. 2021), the involvement of Sirt6-mediated EndoMT in the pathogenesis of diabetic cardiomyopathy had been considered to be critical (Zhang et al. 2020).