UGT1A1 and Hepatic fibrosis: MiR-486-3p expression had been reported to be increased in patients experienced with liver cirrhosis and mice suffered from liver fibrosis, leading to the regulation of detoxification activity by reduction of UGT1A (Paulusch et al. 2021), and the elevated expression of mir-486 was found in the sera of patients with acute myocardial infarction (Hsu et al. 2014).