NOTCH4 functions as a membrane receptor in regulating cell-fate determination, including cell differentiation, proliferation, and apoptosis in vertebrates (Shimizu et al. 2002) and it is overexpressed in various types of cancer, including breast and colorectal cancer (Nagamatsu et al. 2014; Wu et al. 2018). The gene discussed is NOTCH4; the disease is colorectal cancer.