HDAC3 and cirrhosis of liver: In addition, evidence indicates HDAC3 mechanosensitivity.29 Previous studies showed that abnormal matrix stiffness in liver cirrhosis changed HDAC3 expression and the organization of its cytoskeleton.35 Another study indicated that HDAC3 was essential during shear-induced stem cell differentiation.36 However, no studies are available on the role of HDAC3 in chondrocyte senescence regulation and OA progression.