These results indicated that the superior killing of leukemia cells by MCJ KO CD8 CAR-T cells is independent of IFNγ, consistent with previous studies showing IFNγ−independent CAR-T cell activity against some hematologic cancers, although IFNγ has also been reported to contribute to CAR-T cell activity in some solid tumors and some hematologic malignancies74–77. This evidence concerns the gene CD8A and hematopoietic and lymphoid cell neoplasm.