Although the production of kynurenine by tumor cells is considered immunosuppressive for anti-tumor immune response92, kynurenine may be imported from the bloodstream via large amino acid transporter 1 (LAT1 – also known as SLC7A1)93 and may promote β-oxidation inside CD8 T cells94, further exacerbating the MCJ KO metabolic effect on this pathway. Here, LARGE1 is linked to neoplasm.