Consistent with the above results, and in agreement with the idea that fork stabilization is the underlying mechanism of resistance in BRCA- H2AX-deficient tumours, partially inhibitory ATMi concentrations (AZD0156, 5-20 nM) entirely rewired PARPi response in BRCA- H2AX-deficient cells (Fig. 4d; Supplementary Fig. 5c). Here, H2AX is linked to neoplasm.