TPMT and inflammatory bowel disease: Variation in TPMT has been previously associated with adverse reactions to thiopurines in IBD cohorts.26 The detection of TPMT*2 in individuals of Asian ancestry, particularly East Asian, is a relatively uncommon finding.24 Although the allele frequency may be inflated due to the limited sample size of individuals of East Asian genetic ancestry, detection of such PGx variation in TPMT supports the need to further characterize allele frequency and associated clinical outcomes in patients of differing ancestral backgrounds.