To determine whether the phenotype of CRISPR-Cas9-mutated hESC-derived organoids was representative of HNF1B-associated kidney disease, we evaluated organoids generated from hiPSCs derived from a family carrying a heterozygous deletion of exon 9 (HNF1B+/ΔExon9) (Figures S2A–S2C). This evidence concerns the gene HNF1B and kidney disorder.