Regarding SLE clinical features, patients with CVD had longer SLE disease duration (mean 15.4 years vs. 10.3 years) and more features of severe disease, including higher mean serum creatinine (1.42 mg/dL vs. 0.96 mg/dL), presence of autoantibodies (including anti-dsDNA, anti-Ro, and lupus anticoagulant), and hypocomplementemia (low C4). This evidence concerns the gene CALR and systemic lupus erythematosus.