TSP-1 expression is increased in the blood and muscle tissue of patients affected by brachio-cervical inflammatory myopathy and systemic sclerosis (BCIM-SSc), where muscle Thbs1 expression is positively correlated with tissue fibrosis and infiltration of macrophages in the muscle (Suárez-Calvet et al., 2020). The gene discussed is THBS1; the disease is systemic sclerosis.