FABP4 and obesity due to melanocortin 4 receptor deficiency: In murine models, selective overexpression of WNT10B from the fatty-acid binding protein 4 (FABP4) promoter repressed the expression of the adipogenic program in adipocytes, thus impairing adipose tissue development and preventing obesity in mice (Longo et al., 2004; Wright et al., 2007).