Long-term (20-week) HFD-induced obesity led to interstitial accumulation of the lectin family protein galectin-3 (Gal-3), a potent chemoattractant (Takada et al., 2022) involved in cell adhesion, cell cycle progression, apoptosis, inflammation, cell proliferation, and differentiation (Henderson and Sethi 2009). Here, LGALS3 is linked to Obesity.