On the other hand, the ERBB4 gene, or erb-b2 receptor tyrosine kinase 4, is involved in the pathogenesis of amyotrophic lateral sclerosis by a mutation that reduces autophosphorylation on ErbB4 upon neuregulin stimulation (Takahashi et al., 2013). The gene discussed is ERBB4; the disease is amyotrophic lateral sclerosis.