For instance, FN1 and SIK3 are associated with spondyloepiphyseal dysplasia, PADI2 is related to sclerosis, ERBB4 is connected to amyotrophic lateral sclerosis (ALS), and B3GNT2 and BACE1 are associated with muscular dystrophy and muscular inflammation, respectively. The gene discussed is BACE1; the disease is muscular dystrophy.