AR and polycystic ovary syndrome: Using cre-lox transgenics, GABA-specific androgen receptor knockout (GABARKO) mice were generated and exposed to either acute prenatal androgen excess (PNA model) (16, 33) or chronic androgen excess from a peripubertal stage (peripubertal androgen or PPA model) (17, 34, 35) to determine whether AR signaling in GABA neurons is involved in the development of PCOS-like features.