According to expert consensus, the vast majority agree that AP cases with TG levels ≥ 5.6 mmol/L should be suspected as HTG-AP, while cases with TG levels ≥ 11.3 mmol/L are confirmed to be HTG-AP.[6] The intricate pathological mechanism underlying TG and AP involves pancreatic lipase hydrolysis of triglycerides, excessive formation of free fatty acids resulting in inflammatory changes and capillary damage, and potential factors such as hyperviscosity and ischemia, which play crucial roles.[7]. Here, PNLIP is linked to alkaline phosphatase measurement.