IGFBP7 and acute kidney injury: Urinary TIMP-2, and IGFBP-7 demonstrate an AUC of 0.84 for predicting moderate-to-severe AKI, significantly enhancing the predictive performance of the clinical risk prediction model.[53] Furthermore, Yan et al[54] indicated that combining TIMP-2 and IGFBP-7 with clinical findings improved the predictive value of AKI compared to biomarkers alone; the combined model’s AUC (0.86) surpassed that of the individual predictive model.