Meanwhile, the expression levels of IGFBP-7 can be inhibited by gypenoside XLIX to reduce programmed cell death and alleviate cisplatin-induced AKI.[28] Wang et al[29] demonstrated that the overexpression of IGFBP-7 significantly induced cell cycle arrest at the G1-G0 phases and promoted apoptosis in LPS-induced HK-2 cells. The gene discussed is IGFBP7; the disease is acute kidney injury.