IGFBP7 and acute kidney injury: The levels of TIMP-2 × IGFBP-7 were categorized into 3 grades: >2.0, 0.3–2.0, ≤0.3, and demonstrated a significant association with unfavorable long-term consequences.[64] Meersch et al[31] investigated the predictive value of urine TIMP-2 × IGFBP-7 (AUC = 0.79) for RRT before discharge from AKI.