Additionally, IGFBP-7 can be activated by Circ_35953/miR-7219-5p/HOOK3 regulation and participates in the occurrence and development of sepsis-AKI.[30] The current regulatory mechanism depicted in Figure 1 encompasses the proteinuria pathway and gene regulation of TIMP-2 and IGFBP-7 in CSA-AKI. This evidence concerns the gene TIMP2 and acute kidney injury.