The patient’s serum creatinine level changed significantly only 24 hours after surgery.[50] Further statistical analysis showed that the 3-hour urine TIMP-2 × IGFBP-7 of cardiac surgery patients had good specificity and sensitivity for distinguishing AKI patients from non-AKI patients, and the 24-hour urine TIMP-2 × IGFBP-7 had better specificity. The gene discussed is IGFBP7; the disease is acute kidney injury.