However, when combined with urinary IL-18 and TIMP-2 at 2 and 6 hours after pediatric cardiac surgery, the predictive power improved from an AUC of 0.938 to 0.973.[52] This indicates that early stage biomarkers can predict AKI following major cardiac surgery, and utilizing multiple markers in combination can predict AKI. This evidence concerns the gene IL18 and acute kidney injury.