TIMP2 and Sepsis: When sepsis or ischemic injury occurs, they promptly transmit corresponding signals, causing renal tubular cells to arrest in the G1 cell cycle phase momentarily after entry, thus preventing further damage progression.[55] These physiological and pathological mechanisms, along with cellular pathways, elucidate the potential application prospects of TIMP-2 and IGFBP-7 in early AKI prediction.