In view of the predictive ability of TIMP-2 and IGFBP-7 in AKI that has been found, their combination with the conventional indicators of creatinine and urine volume was attempted to enhance the diagnostic accuracy of AKI.[56] The current clinical diagnostic criteria for AKI was formulated by the Global Kidney Disease Improvement Working Group in 2012, and the serum creatinine level should be increased by at least 0.3 mg dL−1 or more than 1.5 times the baseline within 48 hours (known or It is presumed to occur within the first 7 days) or the urine output drops below 0. Here, TIMP2 is linked to acute kidney injury.