The analysis of long-term outcomes revealed that the risks associated with TIMP-2 × IGFBP-7 levels exceeding 2.0 (ng/mL)2/1000 were comparable to the progression of AKI, even in cases where no progression from AKI stage 1 was observed based on serum creatinine (sCr) and urine output. Here, TIMP2 is linked to acute kidney injury.