Researchers using the Kaede system, which tracks the migration of allphotoconverted CD8+ T cells, have demonstrated egress of tumor T cells(including activated, antigen-specific CD8+ T cells) to the lymphoid system(8, 9, 35), consistent with viewsthat effector CD8+ T cells re-enter the recirculating immune system (36, 37). Here, CD8A is linked to neoplasm.