Both fate-mapping strategies revealed antigen-signaled CD8+ T cellclonal populations to be proliferating (Fig. S7B and S7D), to contain a subset ofTcf7 expressing stem-cell like cells with a capacity forself-renewal (38) (Fig. S7C and S7E) and tobe exhausted in the tumor (Fig. 5E). The gene discussed is CD8A; the disease is neoplasm.