For example, the proteins S100A8/S100A9 (aka calprotectin), which are markers of NET release, and which we found to be up-regulated in fatal COVID-19, are targets for Paquinimod, which inhibits S100A8/S100A9, which is involved inflammation and immune regulation (65), and has been shown to be beneficial in mice infected with SARS-CoV-2 (66). Here, S100A8 is linked to COVID-19.