Shen et al. previously reported that the lncRNA CRNDE accelerates IgAN progression by promoting NLRP3 inflammasome activation in macrophages [8], whereas Zhang et al. reported that lncRNA RPPH1 promotes inflammatory response and cell proliferation in mesangial cells in diabetic nephropathy [27], but its role in IgA nephropathy is unclear. The gene discussed is NLRP3; the disease is diabetic kidney disease.