During the early phase of tumor growth (days 7–9), gp96 deletion induced a loss of Treg intratumoral infiltration and significantly augmented the activity of CD8+ TILs, as evidenced by increased CD44hiCD62lo, GZMB+Tcf-1–, ICOS+Tcf-1– effector cell populations and a Ki-67+ proliferating subset (Figure 6C and Supplemental Figure 12, A–F). The gene discussed is ICOS; the disease is neoplasm.