To further understand the role of LFA-1 in mediating Treg trafficking into tumors in human cancers, we compared the transcriptional profiles of various α integrins in tumor-infiltrating and peripheral (PBMC) Tregs isolated via FACS from patients with breast cancer (Gene Expression Omnibus [GEO] GSE89225) (27). The gene discussed is ITGAL; the disease is breast carcinoma.