GSDME has been found highly expressed in most malignant cancers,and an obvious relationship exists between GSDME levels and survivalprognosis of cancer patients.209 Studieshave also shown that GSDME methylation is a valuable molecular biomarkerin cancer, specifically in breast cancer diagnoses,210 with a recent report suggesting its importance in a varietyof other cancer types as well.211 The prominentexpression and methylation properties of GSDME in diverse cancersmake it an emerging favorable prognostic biomarker with a tremendouspotential. This evidence concerns the gene GSDME and cancer.