In breast cancer, enhanced ENO1 expression has been associatedwith greater tumor size and a shorter disease-free interval.195 Patients with lung cancer overexpressing ENO1also exhibited poor clinical outcomes, with shorter overall survival.196 ENO1 overexpression in hepatocellular carcinomacorrelated positively with venous invasion.197 ENO1 overexpression in multiple cancer types, its localization atthe cancer cell surface, and its targetability make this protein arising cancer biomarker and potential target for therapeutic agents.198. This evidence concerns the gene ENO1 and neoplasm.