As for the validation set, the low-risk category had considerably improved OS than the high-risk category based on the KM curves (HR: 3.606; 95% CI 1.629–7.981; P < 0.001) (Fig. 4B). Also, univariate Cox regression analysis implied that SRF was a risk factor for OS in the TCGA-CRC cohort (HR: 2.449; 95% CI 1.701–2.526; P < 0.001) (Fig. 4C). This evidence concerns the gene SRF and colorectal carcinoma.